Yann Le Guen

Dr. Yann Le Guen is the Assistant Director of Computational Biology in the Quantitative Sciences Unit (QSU) at Stanford University. He earned dual MSc degrees in Computer Science from Telecom Paris and in Bioengineering (Neurotechnology track) from Imperial College London, both with Distinction. He then completed his PhD in Medical Imaging and Genomics at Paris-Saclay University, where he studied the genetic underpinnings of brain asymmetries related to language processing.

At Stanford, Dr. Le Guen leads research at the intersection of multi-omics, statistical genetics, and aging-related diseases. His work integrates genomics, transcriptomics (including single-cell and spatial RNA-seq), proteomics, and imaging to identify genetic and molecular drivers of neurodegeneration, lifespan, and resilience. His research has uncovered rare APOE variants protective against Alzheimer’s disease, immune-mediated mechanisms involving HLA-DRB1*04 alleles, and biomarkers of healthy aging.

He collaborates broadly across the School of Medicine and has contributed statistical methods for large-scale omics analysis, including biobank-scale rare variant screening and ancestry-aware risk modeling. Dr. Le Guen is a recipient of several prestigious awards, including a Marie Skłodowska-Curie Global Fellowship and the Alzheimer’s Association Young Investigator Award.